“Novel Nucleobase-Containing Triblock Copolymers: Synthesis and Characterization of Self-Assembled Nanostructures in Aqueous Solutions”

Project Manager: Dr. Theodoros Sentoukas

Project period: 30.09.2021-29.09.2022

The project covers the synthesis and molecular and physicochemical characterization of ABC-type methacrylate terpolymers, including: poly(carboxybetaine methacrylate)-b-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(adenine methacrylate) (PCBMA-b-PDMAEMA-b-PAdMA)
and poly(carboxybetaine methacrylate)-b-poly(2-(dimethylamino)ethyl)-b-poly(thymine methacrylate) (PCBMA-b-PDMAEMA-b-PThMA). The work planned in the project is necessary to understand the self-assembly process of these copolymers, the formation of nanostructures in various aqueous solutions and their stability over time. The obtained nanoparticles can be the basis for the development of nanocarriers for drug or protein delivery systems.